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3 Nanotechnology-enabled strategies to overcome immunosuppressive barriers 3.1 Reprogramming the tumor-associated macrophage compartment Given the central role of M2-polarized TAMs in maintaining immunosuppression within the osteosarcoma TME, strategies to reprogram these cells toward a pro-inflammatory M1 phenotype have attracted considerable attention

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Data availability Data that support the findings of this study are available upon reasonable request from the corresponding authors

For the tracing 13 ,C 3 -serine was added to a final concentration of 100 M and cultured for an additional 6 h of hemin, DMF or both treatments

Study Duration: Up to 12 weeks

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