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Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction

Appetite can become more unpredictable

Steve Small: Yes, a very handy chart there

However, albuminuria is a potent predictor of eGFR decline, so these drugs could delay progression in DKD by reducing albuminuria.99 In a subgroup analysis of the LEADER trial the effect of liraglutide vs

Injecting synthetic GLP-1 can mimic these effects

Lack of long-term data : Despite the positive short- and medium-term results, there is a lack of data on the long-term effects and safety of these treatments