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Some individuals may experience mild discomfort, irritation, or an urge to defecate after inserting a suppository

Occur in 3045% of patients during dose escalation

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The article says they typically see more pronounced effects than those whose weight gain is more metabolic in origin, which follows directly from the medication working on hunger signaling rather than energy expenditure

In patients, liraglutide is administered daily with a target dose of 1.8 mg s.c