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According to the Canadian Adult Obesity Clinical Practice Guidelines, drug therapy for weight management is appropriate for adults with a BMI of 30 or higher, or 27 or higher with at least one weight-related comorbidity

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Following the SUSTAIN-6 findings, the Ozempic Summary of Product Characteristics (SmPC) and specialist ophthalmology guidance emphasise the importance of: Assessing retinopathy status before initiating semaglutide Ensuring patients are up-to-date with diabetic eye screening Considering the rate of anticipated glycaemic improvement More frequent monitoring in high-risk individuals The consensus among UK diabetes specialists is that semaglutide remains an important therapeutic option, but prescribers should exercise particular caution in patients with established retinopathy and poor baseline glycaemic control

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