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doi: 10.1016/j.jpeds.2011.03.049 39 PalladinoAASayedSLevitt KatzLEGallagherPRDe LeonDD

Growth media was replaced with binding buffer [DMEM containing 25 mM HEPES and 0.1% (w/v) BSA] containing 0.1 nM [ 125 I]-exendin(939) and increasing concentrations of unlabelled peptide agonists

A Phase 2 study published in 2023 reported dose-dependent reductions in body weight among trial participants, with the highest dose associated with reductions of up to roughly 24% over 48 weeks

The preferred disposal method is a sharps destruction device, a small portable device that destroys needles at home within a few seconds using high heat

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it's fundamentally about safety and tolerability