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Medical disclaimer: This article is for educational purposes and doesnt replace individualized medical advice

Evidence boundary No controlled trial has tested this combination at any dose for weight loss

Dermatological reactions represent the most consistently documented side effect of excessive B12 intake

Because the IOM bases the RDA on the absorbed amount of B12 necessary to prevent deficiency, its straightforward to calculate the IOMs weekly target absorption

Supporting this with appropriate nutrition, including adequate protein to maintain gut epithelial cell turnover, represents a logical adjunct