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In September 2014, the medication CONTRAVE (naltrexone HCI and bupropion HCI) was approved for use in patients with a body mass index (BMI) of 30 (obesity) or more without weight-related medical conditions or a BMI of 27 or greater with a weight-related medical condition

Neuroscience (2011) 185:97105.10.1016/j.neuroscience.2011.04.041 80 NguyenDAlaviMVKimK-YKangTScottRTNohYHet alA new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

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