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Future research applications will likely expand to include investigation of senescence heterogeneity, tissue-specific senescent cell populations, and the development of personalized approaches to senolytic intervention based on individual senescent cell burden and characteristics

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In general, class I GRXs are enzymatically active as oxidoreductases on small disulfide model substrates like HED or Cys-SG, which functionally discriminates them from class II GRXs 14,15

Diabetes Care 41(2):356363 Karg MV, Bosch A, Kannenkeril D, Striepe K, Ott C, Schneider MP et al (2018) SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial

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They affect a brain chemical called dopamine