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IGF-1 signaling is widely studied because it plays a role in protein synthesis and tissue repair processes

doi: 10.1038/302716a0 22 MojsovSHeinrichGWilsonIBRavazzolaMOrciLHabenerJF

Key findings include: 67% of Omada members were persistent on their medication at one year and experienced weight loss comparable to clinical trials

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It directly stimulates pro-opiomelanocortin/cocaine-and-amphetamine-regulated transcript (POMC/CART) neurons and indirectly inhibits neuropeptide-Y/agouti-related protein (NPY/AgRP) neurons through GABA neurotransmission, reducing appetite and promoting weight loss [40]