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[9] Important safety considerations include monitoring for signs of acute pancreatitis (severe, persistent abdominal pain, sometimes with vomiting) which requires urgent medical assessment, and potential worsening of diabetic retinopathy, particularly in patients with pre-existing retinopathy experiencing rapid improvement in blood glucose control

Allison added the IJO paper is related to the idea of treatment response heterogeneity, a growing field of study

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Ipamorelin is not typically known to directly impact sleep patterns

Tirzepatide may contribute to anxiety through several indirect pathways