Both appear in peptide therapy clinics
157,158 Activation of the insulin or Insulin-like Growth Factor 1 (IGF-1) receptor can enhance insulin sensitivity, improve glucose absorption and utilization by cells, and potentially have positive effects on cardiovascular health and long-term energy balance
Unlike conventional GLP-1 receptor agonists, tirzepatide activates two incretin pathways simultaneously by targeting both GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptors
Why Peptides Work Better Together Before diving into specific stacks, it helps to understand why combination therapy outperforms individual peptides
Tirzepatide is also modified with a C20 fatty diacid side chain, which helps it bind albumin and extends its half-life to about 5 days
Nature 599:120124 Maier L, Pruteanu M, Kuhn M, Zeller G, Telzerow A, Anderson EE, Brochado AR, Fernandez KC, Dose H, Mori H et al (2018) Extensive impact of non-antibiotic drugs on human gut bacteria