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10.1016/j.jconrel.2023.09.011 133 PengZ.WangX.DengQ.YanW.ZhaoW.PuY.et al (2024)
[7] This two-enzyme description applies to mammals and many other organisms, but it is not universal
Any strong, unusual, or unpleasant smell is a clear indicator of contamination or degradation
Most experimental patches use microarray technologythousands of tiny needles that penetrate the outer skin layerbut this still requires regular replacement and carries infection risks similar to injections
The absence of published full-text human clinical trials remains the most significant limitation in the evidence base
This issue is particularly relevant in cases of co-supplementation or the simultaneous use of pharmacological treatment, which often obscures the isolated effect of the supplement under investigation 53
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