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doi:10.1016/j.pneurobio.2014.11.004

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A subsequent pilot study (n=12) comparing oral liposomal glutathione (500 mg twice daily for 2 weeks) found increases in GSH levels in whole blood, erythrocytes, and plasma, along with reductions in 8-isoprostane (a marker of oxidative stress) (Buonocore et al., Oxid Med Cell Longev, 2016) [16]

Restoring adequate levels through injections is a standard medical approach when oral absorption is impaired

Downstream signalling may then include manipulation of IGF-1 pathways, PI3K/Akt and MAPK/ERk cascades or endocrine feedback systems