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However, all temporal and dosing parameters described here derive from animal studies, and optimal administration strategies for research or any other purposes in humans remain undefined without clinical investigation

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Busulfan conjugation by glutathione S-transferases alpha, mu, and pi

Furthermore, GSTs are additionally identified as regulators of cellular signaling pathways, thereby influencing cell proliferation or apoptosis ( in vitro with chemically reactive metabolites derived from several drugs displaying idiosyncratic toxicity, including troglitazone, acetaminophen, clozapine, and diclofenac ( HepG2 cells have been used for decades as a test system for studies involving hepatotoxic compounds

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