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Who Benefits Most Cardiovascular benefits are clearest in high-risk patients: Established cardiovascular disease: Patients with prior heart attack, stroke, or documented atherosclerosis have the strongest evidence for benefit

Users report steady improvements over months rather than dramatic short-term changes, which often indicates sustainable rather than inflammatory response

However, in people with T2D and MASLD, 24 weeks of efinopegdutide 10 mg reduced liver fat content by 72.7% compared to 42.3% reduction with semaglutide 1 mg despite similar WL achieved with both interventions [79]

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Blood pressure-lowering effects of GLP-1 receptor agonists exenatide and liraglutide: a meta-analysis of clinical trials

Kuo et al., 2020