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It is produced by white blood cells (especially neutrophils) and keratinocytes

Turpeinen, A

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NHERF1-mediated functional coupling of CXCR2 and PLC-3 will form a macromolecular complex, which is essential for CXCR2 signal transduction and malignant progression of pancreatic cancer

Front Microbiol 14:1250330 Ciofu O, Moser C, Jensen P, Hiby N (2022) Tolerance and resistance of microbial biofilms

These findings are consistent with the observed decrease in growth rate and biosynthetic capacity in GR mutant strains and may reflect a broader reduction in biosynthetic pathways and cellular regulatory functions