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Its bioavailability is roughly 1% without specific dosing conditions (empty stomach, 120 mL water, 30-minute fast after dosing)

1 This concern emerged in Phase 3 and wasnt seen in Phase 2

Referral to centers of excellence and shared decision-making are important components of surgical consideration

Diabetes mellitus is one of the leading causes of cardiovascular disease, blindness, kidney failure, and amputation of lower limbs

We speculate that excess intrauterine lipid exposure may contribute to hepatic injury, inflammation, impaired mitochondrial function, and impaired hepatocyte development in infants of mothers with obesity

10.1210/en.2018-00004 8 BandayM