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Similar to transcriptomic results from genetic perturbation screens such as Perturb-seq 17 , we noticed that groups of genes whose proteins exist in complexes, or function within the same biological pathways, often produced the same phenotype across multiple infection parameters (Fig 1E)

Six circuits of related organ systems make up the NEM system, and one circuit is the Detoxification circuit

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Thus, current efforts are focused on preserving basal autophagy levels in podocytes, a goal achievable through the administration of antioxidant compounds such as berberine, mangiferin, notoginsenoside R1, and geniposide ( Excessive OS exerts a dual impact on the integrity of the glomerular filtration barrier, both inducing dysfunction and exacerbating proteinuria and renal decline

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