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This is followed by the addition of glycine to the C-terminus of gamma-glutamylcysteine via the enzyme GSH synthetase to form GSH

Glutathione steps in during Phase II, known as the conjugation phase, to neutralize these highly reactive intermediates before they can cause systemic tissue damage

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Vaccinia-related kinase(VRK) is a newly discovered serine-threonine kinase in humans

This cellular priming provides the mechanistic foundation for FOXO4-DRI's selective targeting, enabling researchers to eliminate senescent cells without affecting healthy tissue function