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Non-blue colors (green, brown) indicate degradation requiring disposal

However, Gclc KO mice still lost substantial weight while on an HFD, although to a lesser extent than normal chow (Fig

Sedghi et al, 1993)

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Sulfation The first step is the bioactivation of inorganic sulfate by enzyme called ATP sulforylase to give the coenzyme 3'-phosphoadosine-5-phosphosulfate (PAPS) Sulfation The second step here is the transfer of sulfate group from the coenzyme PABS to the acceptor drug by nucleophilic attack: As in all conjugation reactions: The endogenous polar group must be activated and converted into electrophilic derivative

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