semaglutide microbiome alters gut microbiota and improves NAFLD in db/db mice Gut microbiota mediates semaglutide attenuation

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This class of drugs has become extremely popular due to their effectiveness in both regulating blood sugar and promoting weight loss

The review also reminds us: much of the evidence is observational, so causality isnt fully proven

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Unlike the VLED, semaglutide did not appear to downregulate levels of satiety hormones such as PYY and amylin, and upregulated CCK levels

Factors associated with response to GLP-1 RA treatment Older adults and GLP-1 RA treatment response In elderly patients with overweight or obesity with T2DM, Perna et al