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These treatments can be performed by injecting anti-pigmentation products, laser treatments, chemical peels or topical creams

doi: 10.3390/molecules26102838 16 HlsmeierAJ

In other words, smaller daily doses are better than infrequent higher ones

[1] Other side effects may include flushing (20.3%), injection site reactions (13.2%), headache (11.3%), vomiting (4.8%), cough (3.3%), fatigue (3.2%), hot flashes (2.7%), paresthesia (2.6%), dizziness (2.2%), and nasal congestion (2.1%)