However, endogenous GLP-1 has an extremely short half-life due to rapid degradation by dipeptidyl peptidase-4 and renal clearance
The Phase 3 study, multicentre, 40-week, open-label, randomised, was conducted in 73 sites across six countries
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At Week 26, treatment with tesamorelin resulted in a reduction from baseline in mean trunk fat of 1.0 kg in Study 1 and 0.8 kg in Study 2, respectively (compared with an increase of 0.4 kg in Study 1 and of 0.2 kg in Study 2, respectively, in patients receiving placebo)
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Studies of semaglutide for weight management show the same pattern