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The mechanistic explanation is that the GHRH signal (cAMP pathway) and the GHRP signal (PLC / Ca2+ pathway) are independent and additive at the somatotroph level, and that GHRP increases somatotroph sensitivity to the GHRH signal
Immunity 47 , 498509.e496 (2017)
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Mechanically, ARID1A is a component of the SWI/SNF complex, which binds to the SLC7A11 promoter and promotes NRF2-mediated SLC7A11 transcriptional activation
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