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5 Journal of Endocrinology & Metabolism (2013)Safety & tolerability of AOD-9604 in humans (no IGF-1 increase

Dietrich, Sarah Bugg, Matthew J

doi: 10.3390/antiox12030777 76 RamyaSPoornimaPJananisriAGeofferinaIPBavyataaVDivyaMet al

One of the animal studies saw significant changes in expression levels of Bcl6 , a gene described as playing a main role in the formation and development of the immune system, after the administration of Selank.16 A second animal study, in rats, observed statistically significant increases in anti-inflammatory cytokines.17 The human trial yielded similar results to the aforementioned second rat study in patients with anxiety-asthenic disorders (anxiety and physical weakness).18 Taken together, these studies suggest that Selank can support proper immune function while preventing an excessive immune response (inflammation) that might otherwise damage vital tissues.19 Is Selank safe

n = 8 for vehicle, n = 7 for vehicle+NAC, n = 9 for GGsTop, n = 9 for GGsTop+NAC

Indian J Occup Environ Med