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In both cases, the concern is over the development of a specific type of thyroid cancer involving the parafollicular cells (aka C cells) of the gland

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The changes in median methylmalonic acid (MMA) and total homocysteine (tHcy) levels over time are shown

This shift does not diminish the importance of safety, but it underscores the need to evaluate peptide systems within an appropriate therapeutic context rather than through overly conservative early-stage filters