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A systematic search was conducted in the PubMed and Google Scholar databases from January 2000 to September 2024 via the following search terms:"thermal water,""balneotherapy,""cosmetic effect,""balneotherapy,""spa therapy,""antioxidants,""oxidants/reactive oxygen species,""skin diseases,""in vitro studies,"and"in vivo studies"via OR and AND operators

Orphanet J Rare Dis 8:148

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