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Nevertheless, axitinib combined with BSC led to a significant prolongation of PFS and time to tumor progression (TTP) and an increase of clinical benefit rate (CBR), and the toxicity of patients with advanced HCC is acceptable

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Notably, metformin treatment showed significant regulatory effects on certain pathways, such as regulation of lipolysis in adipocytes, fat digestion and absorption, and vitamin digestion and absorption, which are closely related to the process of lipid metabolism and deposition