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Here is a revised and more accurate explanation of the reasons a UK GP surgery might refuse to give a B12 injection a day earlier than scheduled, incorporating the points youve raised and providing a more scientifically grounded perspective: 1

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It is primarily available for research purposes, and its use in humans carries regulatory and safety considerations

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Will a B12 shot help me lose weight

Despite the short plasma half-life, downstream biological effects in tissue persist substantially longer, consistent with a signaling cascade rather than direct dose-response activity