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The lack of osteogenic response is not due to a reduced osteocyte density (64), suggesting that osteocyte-derived IGF-I not only mediates bone osteoblast/osteocyte differentiation, but also the mechanosensitivity of the cells (Figure 2)

This could theoretically affect DNA methylation, gene expression, and other processes dependent on methylation

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In the second phase, 240 subjects with type 2 diabetes were treated with a placebo