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Qin J, Ma Z, Chen X, Shu S (2023) Microglia activation in central nervous system disorders: a review of recent mechanistic investigations and development efforts

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To obtain the necessary number of animals for the experiment, eight Wistar females were mated with eight Wistar males (1:1, individual cages) after checking the estrous cycle adapted from Marcondes and collaborators (2002)

Clinical evidence remains limited and outcomes vary by patient

For clinical evaluation, the study used a visual analog scale (VAS 0 10 pain scale) (first step, rest, activity) and Foot Function Index (FFI) (pain, disability, activity)