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This is consistent with previous findings that -cell plasticity occurs in common forms of -cell dysfunction, and is caused by the downregulation of FoxO1 that follows hyperglycemia-induced oxidative stress 26

9,10 Additionally, GLP-1 RAs suppress glucagon secretion from the -cells in the pancreas, leading to decreased blood glucose levels

She was on a DMARD and a biologic both at full doses and still having multiple flares per month

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That means, in addition to GLP-1, it targets a hormone called glucose-dependent insulinotropic polypeptide, or GIP, which increases insulin secretion and stimulation, improves fat metabolism and energy expenditure, and helps suppress appetite, Anekwe said

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