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As expected, H 2 O 2 (0.2 mM) exposure disrupted cellular glutathione homeostasis in both HepG2 cells (a human hepatoma cell line) and NCTC1469 cells (a non-transformed mouse hepatocyte cell line), as demonstrated by an increase in the GSSG/GSH ratio over time (Fig

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Both descriptions are partly right, and the second is the more useful one

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When levels drop, the effects show up in ways that feel vague and hard to pin down