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Toxicol ., 1994 , 10 , 415

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Protocol phase 4: maintenance (months 6 through 12 and beyond) Once your tirzepatide dose is stable at maintenance level and your weight loss has begun to plateau, thyroid monitoring can decrease to every 3 to 6 months for the remainder of the first year, then annually if levels remain stable

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Patients: 711 adult patients with T2D receiving metformin alone or metformin with an SGLT-2i were randomized to semaglutide tablets 14 mg (n=285), liraglutide 1.8 mg subcutaneous injection (n=284), or placebo (n=142), all once daily