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Healthcare (Basel, Switzerland) , 9 (9), 1125

The increase of CD86 + M1 macrophages indicates an increase in inflammation as the disease progresses (Kruppa et al., 2023)

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Contrave is indicated for chronic weight management in adults with a body mass index (BMI) of 30 kg/m2 or more (obese) or 27 kg/m2 or more (overweight) with at least one other weight-related risk factor, such as high blood pressure, Type 2 diabetes, or high cholesterol

A group of CDA-HFD mice was euthanized at treatment start to determine baseline levels of MASH ( n = 10, baseline group)