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In July 2023, the European Medicines Agency 206 and the UK Medicines and Healthcare products Regulatory Agency (MHRA) 230 started a review of these medications safety following reports of worsening mood and suicidal behavior observed in GLP-1RA users
Signs of poor conversion or B12 deficiency include: Chronic fatigue Brain fog and poor focus Mood imbalances, anxiety, or depression Numbness or tingling in extremities Elevated homocysteine Poor detoxification For these individuals, Methyl B12 supplementation isnt just helpful its essential
Accessed 10/1/2025, Galanis A, Karapetsas A, Sandaltzopoulos R
Struggling to get the right nutrition on your GLP-1 journey
Sandy Van
Some patients benefit from even slower escalation
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