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Eckert JM, Byer SJ, Clodfelder-Miller BJ, Carroll SL

Not for injection, infusion, or any clinical application

Capsules, on the other hand, must be broken down by stomach acid, delaying the release of the ingredients and potentially bypassing areas of upper GI irritation

It is widely used in topical anti-aging formulations for wrinkle reduction, skin firming, and improved complexion

Participants who started at 1mg and escalated slowly over weeks experienced substantially fewer GI issues than those assigned directly to higher doses

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