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Not all analyses agree
Published radioligand binding and cAMP accumulation assays report EC50 values comparable to native GLP-1, demonstrating that the modifications affect pharmacokinetics rather than receptor pharmacology
Nucl Instr Meth Phy Res B
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Their dietary B12 intake is already limited to fortified foods and supplements
Whilst tirzepatide itself does not directly cause frequent urination, changes in urinary patterns may signal underlying issues requiring medical evaluation
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