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It is commonly explored within advanced longevity protocols

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In recent GLP-1RA trials focusing on patients with obesity, favourable effect on worsening heart failure in HFpEF patients was indicated to be modulated by baseline BMI [32], although the underlying mechanisms that explain the cardiovascular and renal benefits may not necessarily be due to weight loss alone

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Renal and hepatic effects: Long-term or high-dose use has been associated in case reports with adverse effects on kidney and liver function