This has been well documented with insulin therapy and can also occur with GLP-1 receptor agonist injectables
Compared with LIR once a day, once weekly subcutaneous injection of DUL similarly lowers body weight: 2.90 kg (-3.61 kg for LIR) after 26 weeks of treatment (109)
In addition to bodyweight loss through lifestyle interventions, pharmacotherapies targeting adipose tissue, the digestive system (gut-liver axis) and/or inflammation are warranted
Kathryn M, Jackson P, Jerome M (2021) Kinetically guided, ratiometric tuning of fatty acid biosynthesis
Ask your clinician about alcohol, other morning medicines, and any symptoms that need prompt attention
For instance, over 104 weeks with semaglutide 2.4 mg, participants achieved a mean weight loss of around 15% of baseline weight