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Long-Term Clinical Trial Data Building on earlier findings, long-term trials confirm that GLP-1 agonists maintain a strong safety record

Twelve-month persistence with GLP-1 receptor agonists: a systematic review

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Thus, blockade of hepatic portal GLP-1R signaling causes glucose intolerance in rats, suggesting that GLP-1Rs located on nerve terminals in the hepatic portal vein contribute to the incretin action of GLP-1 (Vahl et al., 2007)

A congressional report found that obesity could cost $9.1 trillion over the next 10 years