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What are the optimal drug characteristics of a GLP-1/glucagon co-agonist for the treatment of NAFLD via hepatic GCGR agonism

Depending on the specific semaglutide medication, some may be available for adolescents and adult patients, while others may only be prescribed for adults

The mean oral bioavailability of semaglutide reached 0.4% to 1.0% when co-formulated with 300 mg of SNAC in humans [19]

Excipients q.s 100 g

Putative molecular events include AMPK phosphorylation at Thr172, which may directly activate PGC-1 by phosphorylating Ser571, thereby upregulating mitochondrial transcription factors (NRF1, TFAM)

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