Wound healing applications, supporting recovery from procedures or injuries, may use higher concentrations under professional guidance
AMG 133 functionally inhibits GIP signalling through human and cynomolgus monkey GIPR with similar potency (half maximal inhibitory concentration (IC 50 ) of 42.4 nM and 26.5 nM, respectively), whereas it has more than 20-fold lower potency for inhibition of GIP signalling through rat GIPR (IC 50 = 822 nM) and did not fully antagonize mouse GIPR with concentrations of up to 3 M
doi: 10.1186/1742-2094-9-194 101
The FDA's own scientists had already reviewed all of this data, and recommended against it because of a lack of evidence: "Accordingly, we propose not adding BPC-157 (free base) or BPC-157 acetate to the 503A Bulks List" [12]
As Yaribeygi, Journal of Cellular Physiology emphasized, while mitochondrial peptides hold therapeutic promise, their systemic effects require caution due to the lack of long-term human studies
10.3109/10715762.2013.847528 116 GriffenC.CullenT.HattersleyJ.WeickertM