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Igarashi I, Maejima T, Kai K, Arakawa S, Teranishi M, Sanbuissho A
ACS Infect
When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before
If you are exploring this space, approved options like tirzepatide (Zepbound/Mounjaro) through a prescribing physician are a far safer and more reliable choice
The peptide's activation of ERK1/2 and downstream transcription factors including Egr-1 drives expression of collagen synthesis genes while its enhancement of cellular migration ensures efficient fibroblast recruitment to sites requiring matrix deposition, creating optimal conditions for rapid yet organized tissue reconstruction
