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Even if these approaches are successful in many cases, there is still a subset (3%5% of patients) that progress to therapeutically refractive disease, constituting the so-called TC-related deaths due to the lack of effective treatment. In this view, some efforts are ongoing to identify personalized therapy for refractory patients and drug repositioning represents one of the potential alternatives (Xu et al., 2019)

According to our findings and published data, oral semaglutide at a dose of 14 mg is significantly less effective for weight loss in individuals with obesity than tirzepatide (a dual GLP-1 and GIP agonist)

Six months represents the minimum for meaningful results, but 12 months or longer produces significantly better outcomes

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Tirzepatide, Birth Control, and Pregnancy: What Women Should Know Tirzepatide, Birth Control, and Pregnancy: What Women Should Know Tirzepatide is commonly known by brand names such as Mounjaro and Zepbound

GLP-1RAs have effects on systemic inflammation such as reduction in high-sensitivity C-reactive protein (hs-CRP) that are not mediated by weight loss or glycemic control [15, 27, 28]