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Freezing can cause the benzyl alcohol to separate from the water, and the freeze-thaw cycle can potentially create micro-fractures in the glass vial, compromising its sterility

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Use strictly in a fume hood with appropriate PPE

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However, a recent meta-analysis of 14 randomized, placebo-controlled trials in 2,149 participants with heart failure found that supplemental coenzyme Q 10 (30-300 mg/day) resulted in a 39% reduction in mortality (seven studies), improved exercise capacity (four studies), but had no effect on left ventricular ejection fraction (nine studies) compared to placebo (34)