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Once activated, these receptors initiate intracellular signaling cascades , such as the PI3K-Akt pathway, which are critical for muscle protein synthesis, cellular growth, and survival (Jones & Clemmons, Endocrine Reviews )
Muscle as an endocrine organ: focus on muscle-derived interleukin-6
Once in circulation, IGF-1 LR3 binds to IGF-1 receptors (IGF-1R) located on muscle, bone, and connective tissues
Glutathione is a naturally occurring antioxidant that our bodies produce in small amounts
doi: 10.1084/jem.134.3.713 3 BallatoriN.KranceS