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3.5 Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship
Clinical evidence specifically comparing dual semaglutide-tirzepatide use to tirzepatide monotherapy remains limited because tirzepatide itself is already a dual-receptor agonist
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Tirzepatide should not be used in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2), as these conditions significantly increase thyroid cancer risk
Analysis of blood parameters confirmed improvements in key markers of glucose and lipid metabolism, such as blood lipid levels, cholesterol, liver damage markers, and HOMA-IR
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