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Recognizing Allergic Symptoms vs Normal Responses Distinguishing between concerning symptoms and normal responses prevents both unnecessary worry and delayed response to actual problems

1 Introduction Psoriasis (PsO) is a chronic, immune-mediated inflammatory skin disorder affecting 23% of the global population ( In parallel with this evolving disease concept, growing evidence points to a complex immunometabolic interplay linking dysregulated glucose metabolism, incretin biology, and chronic inflammation in PsO ( Within this framework, incretins particularly glucagon-like peptide-1 (GLP-1) have emerged as key immunometabolic regulators rather than merely glucose-lowering hormones

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GLP-1R agonists effects on cardiovascular events The first pieces of evidence of the potential clinical benefit of GLP-1 agonists have emerged recently, pointing to a decrease of major adverse cardiovascular and cerebrovascular events (MACCE) including stroke, MI, cardiac mortality, acute coronary syndrome, and revascularization procedures

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Niacinamide (vitamin B3) supports NAD+ production, which is involved in cellular energy metabolism and DNA repair