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These experiments with collagenase resulted in a remarkable reduction in the size of the PD plaque, along with microscopic fraying and dispersal of collagen bundles, when compared with plaques injected with normal saline

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others raise concerns that the drugs worsen symptoms

Preclinical mechanism involves multiple pathways, most notably angiogenesis, nitric oxide signaling, anti-inflammatory effects, and oxidative stress reduction

Aliment Pharmacol